Amar is a herbo-mineral formulation derived from Rasa Shastra in Ayurveda. The formulation is prepared using Mercury (Parad), Copper (Tamra) and Sulphur (Gandhak) as raw materials along with Lufta echinata Roxb. (devdali), Clitoria ternatea L. (aprajita) and lemon juice as consumable herbs.
Devdali and Aprajita
Mercury and Copper are amalgamated after adding Sulphur and ground in lemon juice with extracts of Devdali and Aprajita. After grinding, the mixture is dried under the sun and subjected to heating for 12 to 60 hours at a temperature of 365 to 400 degree Celsius before repeating the grinding process. This cycle is repeated hundred times before the final product can be obtained. The process is known as gandhak jarana.
Traditional Grinding and Heating
Various research works have been carried out to understand the chemistry behind the efficacy of Amar and develop it further.
Process standardization and characterization
Three batches were prepared to ascertain reproducibility. The analysis of raw materials, in-process and final products showed that there was sequential disappearance of metals during the process. The finished product showed no free metal and comprised of minerals only.
Chemical composition of finished product
A patent for this formulation has been filed with competent authorities.
Acute, sub-acute and chronic toxicity studies have been carried on rats to determine the safety profile of Amar. These studies have shown that the formulation is completely safe for human consumption at doses up to more than three times of that being administered.
Experimental Efficacy Studies
Two consecutive experimental studies were carried to evaluate protective properties of Amar in L-Arginine induced Chronic Pancreatitis in male albino wistar rats.
Groups and Dose schedule
Amar depicts significant pancreatitis protective properties in comparison to Methyprednisolone in L-Arginine induced Chronic Pancreatitis in rats. The efficacy was maximum at the dose of 3-4 mg/kg body weight. Interestingly, efficacy decreased on increasing (>4) or decreasing (<3) the dose.
Upcoming Clinical Trial
Study protocol for the randomized controlled clinical trial has been approved by Program Advisory Committee headed by Dr V. M. Katoch, Former Secretary, Department of Health Research, GOI and Former Director General, Indian Council of Medical Research, GOI. The protocol has also received ethical nod from ethical committee of SP Medical College and Hospital, Bikaner and the trial will begin soon under renowned gastroenterologist, Dr SushiI Falodia.